| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374061 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
A series of 4-amino-pyrido[2,3-d]pyrimidin-5(8H)-ones were designed and synthesized as a novel class of inhibitors of NAD+-dependent DNA ligase that possess potency against Gram-positive bacteria.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part 2: 4-Amino-pyrido[2,3-d]pyrimidin-5(8H)-ones](/preview/png/1374061.png "First Page Preview: Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part 2: 4-Amino-pyrido[2,3-d]pyrimidin-5(8H)-ones")
Authors
Tiansheng Wang, Leonard Duncan, Wenxin Gu, Hardwin O’Dowd, Yunyi Wei, Emanuele Perola, Jonathan Parsons, Christian H. Gross, Cameron Stuver Moody, S.J. Ryan Arends, Paul S. Charifson,