| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374065 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
Several novel tetrahydro-β-carboline derivatives with amino acid residues at the 2-position and a glucosamine group at the 3-position of the tetrahydro-β-carboline nucleus were synthesized from a readily available starting material, tryptophane, and were evaluated for their anti-inflammatory activity in the present study. Our results showed that all of the derivatives tested exhibited a significant inhibition of xylene-induced inflammation in mice.
Graphical abstractTetrahydro-β carboline was modified with amino acids and glucosamine and several novel tetrahydro-β carboline derivatives were obtained. Wherein AA = alanine, glycine.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Li Zeng, Jianwei Zhang,