| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374076 | Bioorganic & Medicinal Chemistry Letters | 2012 | 6 Pages |
A series of bis-oxy cyclophane diamides with bis(aminomethyl)m-terphenyl as spacer have been synthesized and characterized from spectral and analytical data. All the cyclophane diamides exhibit better anti-arthritic activity than the reference drug viz. diclofenac sodium. Some of the cyclophane diamides exhibit good anti-inflammatory activity. The cyclophane amide 4 and 5 do not show any evidence of mutagenicity and cytotoxicity.
Graphical abstractSeries of bis-oxy cyclophane diamides with m-terphenyl diamine as spacer have been synthesized. All the cyclophane diamides show good anti-inflammatory activity and some of the cyclophane diamides exhibited better anti-arthritic activity than the reference drug viz. diclofenac sodium. The cyclophane amide 4 and 5 do not show any evidence of mutagenicity and cytotoxicity in the assays employed.Figure optionsDownload full-size imageDownload as PowerPoint slide
