| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374084 | Bioorganic & Medicinal Chemistry Letters | 2012 | 6 Pages |
Abstract
We describe a new class of NO-donor hypoglycemic products obtained by joining tolbutamide, a typical hypoglycemic sulfonylurea, with a NO-donor moiety through a hard link. As NO-donors we chose either furoxan (1,2,5-oxadiazole 2-oxide) derivatives or the classical nitrooxy function. A preliminary biological characterization of these compounds, including stimulation of insulin release from cultured rat pancreatic β-cells and in vitro vasodilator and anti-aggregatory activities, is reported.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yasinalli Tamboli, Loretta Lazzarato, Elisabetta Marini, Stefano Guglielmo, Michela Novelli, Pascale Beffy, Pellegrino Masiello, Roberta Fruttero, Alberto Gasco,