| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374098 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
A series of 2-aminoquinoline compounds was prepared and evaluated in MCH1R binding and functional antagonist assays. Small dialkyl, methylalkyl, methylcycloalkyl, and cyclic amines were tolerated at the quinoline 2-position. The in vivo efficacy of compound 12 was explored and compared to that of a related inactive analog to determine their effects on food intake and body weight in rodents.
Graphical abstractStructure–activity relationships and in vivo activity of 2-aminoquinoline MCH1R antagonists are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Jinlong Jiang, Myle Hoang, Jonathan R. Young, Danny Chaung, Ronsar Eid, Cherilyn Turner, Peter Lin, Xinchun Tong, Junying Wang, Carina Tan, Scott Feighner, Oksana Palyha, Donna L. Hreniuk, Jie Pan, Andreas W. Sailer, Douglas J. MacNeil, Andrew Howard,