| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374112 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Horseradish peroxidase (HRP) inhibition and glutathione peroxidase (GPx) activities of ebselen and some related derivatives are described. These studies show that ebselen and ebselen ditelluride (EbTe2) with significant antioxidant activity, inhibit the HRP-catalyzed oxidation reactions. In addition, inhibition of lipid peroxidation and singlet oxygen quenching studies were carried out. Although the inhibition of HRP by ebselen is comparable with that of EbTe2, the inhibitory effect on γ-radiation induced lipid peroxidation and the GPx activity of ebselen is found to be much higher than that of EbTe2.
Graphical abstractHorseradish peroxidase (HRP) inhibition and glutathione peroxidase (GPx) activities of ebselen and some related derivatives are described. These studies show that ebselen and ebselen ditelluride (EbTe2) with significant antioxidant activity, inhibit the HRP-catalyzed oxidation reactions. In addition, inhibition of lipid peroxidation and singlet oxygen quenching studies were carried out. Although the inhibition of HRP by ebselen is comparable with that of EbTe2, the inhibitory effect on γ-radiation induced lipid peroxidation and the GPx activity of ebselen is found to be much higher than that of EbTe2.Figure optionsDownload full-size imageDownload as PowerPoint slide
