| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374121 | Bioorganic & Medicinal Chemistry Letters | 2006 | 6 Pages |
Abstract
The synthesis of several novel aza-stilbene derivatives was carried out. The compounds were tested for their c-RAF enzyme inhibition. Compound 27 possesses significant potency against c-RAF and demonstrates selectivity over other protein kinases. A hypothesis for the binding mode, activity, and selectivity is proposed.
Graphical abstractCompound 27 possesses significant potency against c-RAF and demonstrates selectivity over other protein kinases. A hypothesis for the binding mode, activity, and selectivity is proposed.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Octerloney McDonald, Karen Lackey, Ronda Davis-Ward, Edgar Wood, Vicente Samano, Patrick Maloney, Felix Deanda, Robert Hunter,