| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374122 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
A series of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones were synthesized and tested for their antimalarial properties. These compounds showed remarkable anti-plasmodial activity in vitro especially against chloroquine-resistant strains. Their potent biological activity makes them promising lead structures for the development of new antimalarial drugs.
Graphical abstractA series of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones were synthesized and tested for their antimalarial activity. These compounds showed remarkable anti-plasmodial activity in vitro especially against choroquine-resistant strains.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sandra Gemma, Gagan Kukreja, Caterina Fattorusso, Marco Persico, Maria P. Romano, Maria Altarelli, Luisa Savini, Giuseppe Campiani, Ernesto Fattorusso, Nicoletta Basilico, Donatella Taramelli, Vanessa Yardley, Stefania Butini,