| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374125 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
Three novel (1–3) and two known (4–5) scalarane sesterterpenes were isolated from a marine sponge of the genus Spongia. The isolated compounds showed potent inhibition of transactivation for the nuclear hormone receptor, FXR (farnesoid X-activated receptor), which is a promising drug target to treat hypercholesterolemia in humans.
Graphical abstractThe isolation and structures of three novel scalarane sesterterpenes 1–3 and their inhibition of FXR transactivation are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sang-Jip Nam, Hyunsil Ko, Mihee Shin, Jungyeob Ham, Jungwook Chin, Youngshin Kim, Heeyoung Kim, Kyoungjin Shin, Hyukjae Choi, Heonjoong Kang,