| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374127 | Bioorganic & Medicinal Chemistry Letters | 2006 | 6 Pages |
Abstract
A series of structurally novel and metabolically stable bridged bicyclic carbocycle and heterocycle adamantane replacements have been synthesized and biologically evaluated. Several of these compounds exhibit excellent human and mouse 11β-HSD1 potency and 11β-HSD2 selectivity.
Graphical abstractA series of structurally novel and metabolically stable bridged bicyclic carbocycle and heterocycle adamantane replacements have been synthesized and biologically evaluated. Several of these compounds exhibit excellent human and mouse 11β-HSD1 potency and 11β-HSD2 selectivity.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Vince S.C. Yeh, Ravi Kurukulasuriya, David Madar, Jyoti R. Patel, Steven Fung, Katina Monzon, William Chiou, Jiahong Wang, Peer Jacobson, Hing L. Sham, J.T. Link,