| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374128 | Bioorganic & Medicinal Chemistry Letters | 2006 | 6 Pages |
Abstract
A series of metabolically stable adamantane amide 11β-HSD1 inhibitors have been synthesized and biologically evaluated. These compounds exhibit excellent HSD1 potency and HSD2 selectivity and good pharmacokinetic and pharmacodynamic profiles.
Graphical abstractA series of metabolically stable adamantane amide 11β-HSD1 inhibitors have been synthesized and biologically evaluated. These compounds exhibit excellent HSD1 potency and HSD2 selectivity and good pharmacokinetic and pharmacodynamic profiles.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
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Authors
Vince S.C. Yeh, Jyoti R. Patel, Hong Yong, Ravi Kurukulasuriya, Steven Fung, Katina Monzon, William Chiou, Jiahong Wang, Deanne Stolarik, Hovis Imade, David Beno, Michael Brune, Peer Jacobson, Hing Sham, J.T. Link,