Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1374129 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
Four kinds of N-dansyl-amino acid-modified β-cyclodextrins (β-CDs) were prepared as fluorescent chemosensors for chiral discrimination. The use of an amino acid as a spacer improved binding affinities and chiral discrimination abilities of the chemosensors. N-dansyl-l-Phe-modified β-CD showed high d-selectivity for norbornane derivatives and N-dansyl-d-Phe-modified β-CD showed high l-selectivity for menthol. Microcalorimetric titration results indicate that the chemosensors selectively accommodate the enantiomer that induces the least unfavorable entropy change on making an inclusion complex.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hiroshi Ikeda, Qun Li, Akihiko Ueno,