| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374131 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
A series of novel aminobenzimidazoles was prepared and evaluated for h-MCH-R1 antagonist properties. Most of the compounds showed excellent h-MCH-R1 binding affinity as well as mouse ex vivo binding. Compounds 9 and 18 were active in mouse DIO studies at 30 mpk.
Graphical abstractA series of potent and highly selective melanin-concentrating hormone (MCH) inhibitors is described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
T.K. Sasikumar, Li Qiang, Duane A. Burnett, William J. Greenlee, Brian E. Hawes, Timothy J. Kowalski, Kim O’Neill, Brian D. Spar, Blair Weig,