Article ID Journal Published Year Pages File Type
1374136 Bioorganic & Medicinal Chemistry Letters 2006 6 Pages PDF
Abstract

Structure–activity relationships of the 3,5-diamino-piperidinyl triazine series, a novel class of bacterial translation inhibitors, are described. Optimization was focused on the triazine C-4 position in which aromatic substituents that contained electron-withdrawing groups led to potent inhibitors. The initial lack of antibacterial activity was correlated with poor cellular penetration. Whole cell antibacterial activity was achieved by linking additional aromatic moieties at the triazine C-4 position.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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