Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1374136 | Bioorganic & Medicinal Chemistry Letters | 2006 | 6 Pages |
Abstract
Structure–activity relationships of the 3,5-diamino-piperidinyl triazine series, a novel class of bacterial translation inhibitors, are described. Optimization was focused on the triazine C-4 position in which aromatic substituents that contained electron-withdrawing groups led to potent inhibitors. The initial lack of antibacterial activity was correlated with poor cellular penetration. Whole cell antibacterial activity was achieved by linking additional aromatic moieties at the triazine C-4 position.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yuefen Zhou, Zhongxiang Sun, Jamie M. Froelich, Thomas Hermann, Daniel Wall,