| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374139 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
A new sub-class of p38 inhibitors represented by 7-amino-naphthyridone have been discovered. Benchmark compound 16 potently inhibited p38 in vitro, was functionally active, and displayed excellent pharmacokinetic profiles in two animal species. Compound 16 reduced inflammation in animal disease models at EC50 doses as low as 0.2 mpk.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Swaminathan R. Natarajan, Luping Liu, Mark Levorse, James E. Thompson, Edward A. O’Neill, Stephen J. O’Keefe, Kalpit A. Vora, Raymond Cvetovich, John Y. Chung, Ester Carballo-Jane, Denise M. Visco,