Article ID Journal Published Year Pages File Type
1374156 Bioorganic & Medicinal Chemistry Letters 2009 4 Pages PDF
Abstract

G-quadruplexes are unusual structures formed from guanine-rich sequences of nucleic acids. G-quadruplexes have been postulated to play important roles in a number of biological systems including gene regulation and the inhibition of enzyme function. Recently, our laboratory reported on the synthesis and evaluation of a triaza-cyclopentaphenanthrene compound which bound to G-quadruplexes with good affinity and selectivity. This compound contains a 4-pyridone group which has not been previously utilized in other quadruplex binding agents. In this Letter, we describe the synthesis and evaluation of 4-pyridone containing 2- and 3-carboxy-benzoquinolines as G-quadruplex binding agents. We find that these compounds are capable of binding G-quadruplexes with a Ka in the range of 3 × 105 M−1 and with a 10-fold selectivity for quadruplex over duplex DNA.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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