Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1374162 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
Several series of CCR5 antagonists have been discovered by derivatization at the N-terminal of the piperidine ring of the core template 2. Some derivatives exhibited potent inhibition against HIV-1infection. The pharmacokinetic properties of the lead compounds 11a, 14a, 15b, and 16b have been evaluated in vivo.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Maosheng Duan, Christopher Aquino, Robert Ferris, Wieslaw M. Kazmierski, Terry Kenakin, Cecilia Koble, Pat Wheelan, Chris Watson, Michael Youngman,