| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374163 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
The nucleolytic activity of an unnatural ferrocenyl amino acid can be significantly enhanced under reducing or Fenton conditions while exploiting different mechanisms of DNA cleavage. In addition, results from high resolution electrophoresis indicate that the ferrocenyl amino acid exhibits non-sequence specific cleavage of the DNA backbone.
Graphical abstractThe nucleolytic activity exhibited by an unnatural ferrocenyl amino acid is non-specific along the DNA backbone and can be significantly enhanced under reducing and Fenton conditions.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Pamela J. Higgins, Amanda M. Gellett,