| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374165 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
Platensimycin (1) displays antibacterial activity due to its inhibition of the elongation condensing enzyme (FabF), a novel mode of action that could potentially lead to a breakthrough in developing a new generation of antibiotics. The medicinal chemistry efforts were focused on the modification of the enone moiety of platensimycin and several analogs showed significant activity against FabF and possess antibacterial activity.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hong C. Shen, Fa-Xiang Ding, Sheo B. Singh, Gopalakrishnan Parthasarathy, Stephen M. Soisson, Sookhee N. Ha, Xun Chen, Srinivas Kodali, Jun Wang, Karen Dorso, James R. Tata, Milton L. Hammond, Malcolm MacCoss, Steven L. Colletti,