| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374170 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
In this Letter, we assessed newly synthesized sphingolipid analogs as ligands for peroxisome proliferator-activated receptor (PPAR)α, PPARβ or PPARγ, using a dual-luciferase reporter system. We tested 640 sphingolipid analogs for ligand activity. As a result, seven types: A9, B9, C9, C50, F66, G66 and H66, were found to show agonistic activities for PPARs.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kiyomi Tsuji, Shigeru Satoh, Susumu Mitsutake, Itsuo Murakami, Jeong-Ju Park, Qian Li, Young-Tae Chang, Sung-Kee Chung, Yasuyuki Igarashi,