| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374179 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
The purpose of this study was to prepare and characterize antioxidant nanospheres composed of multiple α-lipoic acid-containing compounds (mALAs). It was found that the nanospheres were remarkably stable under physiologic conditions, maintained the antioxidant property of α-lipoic acid, and could be destabilized oxidatively and enzymatically. The preparations were simple and highly reproducible providing a new strategy for the development of nanometer-sized antioxidant biomaterials. The nanospheres may find applications as antioxidant therapeutics and oxidation-responsive antioxidant nanocontainers in drug delivery for pathological conditions characterized by oxidative stress including cancer and neurodegenerative diseases.
Graphcial abstractReactive oxygen species (ROS)-sensitive antioxidant nanospheres were prepared from multiple α-lipoic acid-containing antioxidant compounds (mALAs) by using spontaneous emulsification.Figure optionsDownload full-size imageDownload as PowerPoint slide
