| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374181 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
Exploration of multiple regions of a bi-aryl amine template led to the identification of highly potent M3 muscarinic acetylcholine receptor antagonists such as 14 (pA2 = 11.0) possessing good sub-type selectivity for M3 over M2. The structure–activity relationships (SAR) and optimization of the bi-aryl amine series are described.
Graphical abstractExploration of multiple regions of a bi-aryl amine template led to the identification of highly potent M3 muscarinic acetylcholine receptor antagonists such as 14 possessing good sub-type selectivity for M3 over M2. The structure–activity relationships and optimization of the bi-aryl amine series are described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
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Authors
Brian Budzik, Yonghui Wang, Dongchuan Shi, Feng Wang, Haibo Xie, Zehong Wan, Chongye Zhu, James J. Foley, Parvathi Nuthulaganti, Lorena A. Kallal, Henry M. Sarau, Dwight M. Morrow, Michael L. Moore, Ralph A. Rivero, Michael Palovich, Michael Salmon,