| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374183 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
A series of thiophene PLK1 inhibitors was optimized for increased solubility and reduced protein binding through the appendage of basic amine functionality. Interesting selectivity between PLK1 and PLK3 was also obtained through these modifications.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kyle A. Emmitte, George M. Adjebang, C. Webb Andrews, Jennifer G. Badiang Alberti, Ramesh Bambal, Stanley D. Chamberlain, Ronda G. Davis-Ward, Hamilton D. Dickson, Daniel F. Hassler, Keith R. Hornberger, Jeffrey R. Jackson, Kevin W. Kuntz,