| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374184 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
A series of new 4″,11-di-O-arylalkylcarbamoyl azithromycin derivatives were designed, synthesized and evaluated for their in vitro antibacterial activities. Some derivatives exhibited greatly improved activity against erythromycin-resistant bacteria. Among them, compounds 5f and 5k were found to have potent activity against erythromycin-resistant Streptococcus pneumoniae whose resistance was encoded by the erm or mef gene.
Graphical abstractA series of new 4″,11-di-O-arylalkylcarbamoyl azithromycin derivatives were designed, synthesized and evaluated for their in vitro antibacterial activities. Some derivatives exhibited greatly improved activity against erythromycin-resistant Streptococcus pneumoniae encoded by the erm or mef gene.Figure optionsDownload full-size imageDownload as PowerPoint slide
