[18F]FEAC and [18F]FEDAC: Two novel positron emission tomography ligands for peripheral-type benzodiazepine receptor in the brain

[18F]FEAC ([18F]4a) and [18F]FEDAC ([18F]4b) were developed as two novel positron emission tomography (PET) ligands for peripheral-type benzodiazepine receptor (PBR). [18F]4a and [18F]4b were synthesized by fluoroethylation of precursors 8a and 8b with [18F]FCH2CH2Br ([18F]9), respectively. Small-animal PET scan for a neuroinflammatory rat model showed that the two radioligands had high uptakes of radioactivity in the kainic acid-infused striatum, a brain region where PBR density was increased.

Graphical abstract[18F]FEAC ([18F]4a) and [18F]FEDAC ([18F]4b), two potent PET ligands for peripheral-type benzodiazepine receptor, were synthesized and evaluated.Figure optionsDownload full-size imageDownload as PowerPoint slide