| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374198 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
A series of benzofuran-based farnesyltransferase inhibitors have been designed and synthesized as antitumor agents. Among them, 11f showed the most potent enzyme inhibitory activity (IC50 = 1.1 nM) and antitumor activity in human cancer xenografts in mice.
Graphical abstractThe synthesis and biological activity of benzofuran derivatives as farnesyltransferase inhibitor is described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kohsuke Asoh, Masami Kohchi, Ikumi Hyoudoh, Tatsuo Ohtsuka, Miyako Masubuchi, Kenichi Kawasaki, Hirosato Ebiike, Yasuhiko Shiratori, Takaaki A. Fukami, Osamu Kondoh, Toshiyuki Tsukaguchi, Nobuya Ishii, Yuko Aoki, Nobuo Shimma, Masahiro Sakaitani,