| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374201 | Bioorganic & Medicinal Chemistry Letters | 2009 | 6 Pages |
Abstract
The separation of atropisomeric conformers of 1,2,3,4-tetrahydroisoquinoline amide Bcl-2 ligands allowed the identification of the bioactive conformer which was subsequently confirmed by X-ray crystallography.
Graphical abstractDetermination of the bioactive conformation of a series of atropisomeric Bcl-2 inhibitors is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
John Porter, Andrew Payne, Ian Whitcombe, Ben de Candole, Daniel Ford, Rachel Garlish, Adam Hold, Brian Hutchinson, Graham Trevitt, James Turner, Chloe Edwards, Clare Watkins, Jeremy Davis, Colin Stubberfield,