| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374203 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
The RNA replication machinery of HCV is a multi-subunit membrane–associated complex. NS5A has emerged as an active component of HCV replicase, possibly involved in regulation of viral replication and resistance to the antiviral effect of interferon. We report here substituted piperazinyl-N-(aryl)benzamides as potent inhibitors of HCV replication exerted via modulation of the dimerization of NS5A.
Graphical abstractWe report here synthesis and SAR of substituted piperazinyl-N-(aryl)benzamides as potent inhibitors of HCV replication exerted via modulation of the dimerization of NS5A.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Immacolata Conte, Claudio Giuliano, Caterina Ercolani, Frank Narjes, Uwe Koch, Michael Rowley, Sergio Altamura, Raffaele De Francesco, Petra Neddermann, Giovanni Migliaccio, Ian Stansfield,