| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374209 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
The use of a 1,3,4-oxadiazole in combination with an 8-hydroxy-1,6-naphthyridine ring system has been shown to deliver potent enzyme and antiviral activity through inhibition of viral DNA integration. This report presents a detailed structure–activity investigation of the C5 position resulting in low nM potency for several analogs with an excellent therapeutic index.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Brian A. Johns, Jason G. Weatherhead, Scott H. Allen, James B. Thompson, Edward P. Garvey, Scott A. Foster, Jerry L. Jeffrey, Wayne H. Miller,