Article ID Journal Published Year Pages File Type
1374210 Bioorganic & Medicinal Chemistry Letters 2009 4 Pages PDF
Abstract

Based on the results of computational docking to the active site of the cytochrome P450 14α-demethylase (CYP51), a series of 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted benzylamino-2-propanols as analogs of fluconazole were designed, synthesized, and evaluated as antifungal agents. Results of preliminary antifungal tests against eight human pathogenic fungi in vitro showed that all the title compounds exhibited excellent activities with broad spectrum.

Graphical abstractA number of novel triazole derivatives have been synthesized and studied with molecular docking to get the insight of structural requirements for better enzyme inhibition.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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