Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1374210 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
Based on the results of computational docking to the active site of the cytochrome P450 14α-demethylase (CYP51), a series of 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted benzylamino-2-propanols as analogs of fluconazole were designed, synthesized, and evaluated as antifungal agents. Results of preliminary antifungal tests against eight human pathogenic fungi in vitro showed that all the title compounds exhibited excellent activities with broad spectrum.
Graphical abstractA number of novel triazole derivatives have been synthesized and studied with molecular docking to get the insight of structural requirements for better enzyme inhibition.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Xiaoyun Chai, Jun Zhang, Shichong Yu, Honggang Hu, Yan Zou, Qingjie Zhao, Zhigang Dan, Dazhi Zhang, Qiuye Wu,