| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374245 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
We have synthesized and biologically evaluated 1,4-diazepane derivatives as T-type calcium channel blockers. In this study, we discovered compound 4s, a potential T-type calcium channel blocker with good selectivity over hERG and N-type calcium channels. In addition, it exhibited favorable pharmacokinetic characteristics for further investigation of T-type calcium channel related diseases.
Graphical abstractWe have synthesized and biologically evaluated 1,4-diazepane derivatives as T-type calcium channel blockers. In this study, we discovered compound 4s, a potential T-type calcium channel blocker with good selectivity over hERG and N-type calcium channels. In addition, it exhibited favorable pharmacokinetic characteristics for further investigation of T-type calcium channel related diseases.Figure optionsDownload full-size imageDownload as PowerPoint slide
