| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374259 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
The development and synthesis of potent p38α MAP kinase inhibitors containing a 2H-quinolizin-2-one platform is described. Evolution of the 2H-quinolizin-2-one series from an early lead to solving off target activity and pharmacokinetic issues is also discussed.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Robert M. Tynebor, Meng-Hsin Chen, Swaminathan R. Natarajan, Edward A. O’Neill, James E. Thompson, Catherine E. Fitzgerald, Stephen J. O’Keefe, James B. Doherty,