| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374265 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
Tricyclic pyrazole tetrazoles which are potent partial agonists of the high affinity niacin receptor, GPR109a, have been discovered and optimized. One of these compounds has proven to be effective at lowering free fatty acids in vitro and in vivo.
Graphical abstractTricyclic pyrazole tetrazoles which are potent partial agonists of the high affinity niacin receptor, GPR109a, have been discovered and optimized. One of these compounds has proven to be effective at lowering free fatty acids in vitro and in vivo.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
P. Douglas Boatman, Thomas O. Schrader, Michelle Kasem, Benjamin R. Johnson, Philip J. Skinner, Jae-Kyu Jung, Jerry Xu, Martin C. Cherrier, Peter J. Webb, Graeme Semple, Carleton R. Sage, Jens Knudsen, Ruoping Chen, Andrew K. Taggart,