Inhibition of antigen-induced degranulation by aryl compounds isolated from the bark of Betula platyphylla in RBL-2H3 cells

The methanolic extract of the bark of Betula platyphylla was found to suppress antigen mediated degranulation of RBL-2H3 cells. Four arylbutanoids (1–4) and eight diarylhepatonoids (5–12) were isolated from the methanolic extract using bioassay-guided fractionation. Among them, compounds 4 and 12 were isolated and assigned for the first time. Compounds 1, 2, 3, 5, 10, and 12 showed remarkable inhibitory activity against the degranulation of RBL-2H3 by antigen stimulation in a dose dependent manner at the concentrations ranging from 10 μM to 100 μM.

Graphical abstractA series of arylbutanoids and diarylheptanoids was isolated from the bark of Betula platyphylla. These compounds showed significant inhibitory activity against antigen-induced degranulation of RBL-2H3 cells.Figure optionsDownload full-size imageDownload as PowerPoint slide