| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374292 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
SAR around non-peptidic potent bombesin receptor subtype-3 (BRS-3) agonist lead 2 is presented. Attempts to replace the carboxylic acid with heterocyclic isosteres to improve oral bioavailability and brain penetration are described.
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Related Topics
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Chemistry
Organic Chemistry
Authors
Mark Hadden, Allan Goodman, Cheng Guo, Peter R. Guzzo, Alan J. Henderson, Kevin Pattamana, Megan Ruenz, Bruce J. Sargent, Brian Swenson, Larry Yet, Jian Liu, Shuwen He, Iyassu K. Sebhat, Linus S. Lin, Constantin Tamvakopoulos, Qianping Peng, Yanqing Kan,