| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374296 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
PDE4 inhibitors have the potential to alleviate the symptoms and underlying inflammation associated with dry eye. Disclosed herein is the development of a novel series of water-soluble PDE4 inhibitors. Our studies led to the discovery of coumarin 18, which is effective in a rabbit model of dry eye and a tear secretion test in rats.
Graphical abstractThe development of a novel series of water-soluble PDE4 inhibitors led to the discovery of coumarin 18, which is effective in a rabbit model of dry eye and a tear secretion test in rats.Figure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Steven P. Govek, Guy Oshiro, John V. Anzola, Clay Beauregard, Jasmine Chen, Avery R. Coyle, Daniel A. Gamache, Mark R. Hellberg, Jennifer N. Hsien, Julia M. Lerch, John C. Liao, James W. Malecha, Lena M. Staszewski, David J. Thomas, John M. Yanni,