| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374301 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
In silico analysis of ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate (2) predicts that this molecule should be successfully docked in the PAS, and easily accommodated in the CAS of AChE. The synthesis and the AChE/BuChE inhibition studies are reported, confirming that compound 2 is a potent and selective AChE inhibitor, and consequently, a new lead compound for further development into new dual CAS/PAS cholinergic agents for the treatment of Alzheimer's disease.
Related Topics
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![Molecular modelling, synthesis and acetylcholinesterase inhibition of ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate](/preview/png/1374301.png "First Page Preview: Molecular modelling, synthesis and acetylcholinesterase inhibition of ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate")
Authors
Elena Soriano, Abdelouahid Samadi, Mourad Chioua, Cristóbal de los RÃos, José Marco-Contelles,