| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374302 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
In this work we developed a 3D-pharmacophore model for σ2 receptor based on 19 benzooxazolone derivatives. The best 3D-pharmacophore hypothesis, consisting of five features: a positive ionizable, a hydrogen bond acceptor, a hydrophobic aromatic, a hydrophobic aliphatic, and a generic hydrophobic provided a 3D-QSAR model with a correlation coefficient of 0.97 and a RMSD of 0.48.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
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Authors
Erik Laurini, Daniele Zampieri, Maria Grazia Mamolo, Luciano Vio, Caterina Zanette, Chiara Florio, Paola Posocco, Maurizio Fermeglia, Sabrina Pricl,