| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374305 | Bioorganic & Medicinal Chemistry Letters | 2010 | 6 Pages |
Abstract
We describe the structure–activity relationship of the C1-group of pyrano[3,4-b]indole based inhibitors of HCV NS5B polymerase. Further exploration of the allosteric binding site led to the discovery of the significantly more potent compound 12.
Graphical abstractWe describe the structure–activity relationship of the C1-group of pyrano[3,4-b]indole based inhibitors of HCV NS5B polymerase. Further exploration of the allosteric binding site led to the discovery of the significantly more potent compound 12.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
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Authors
Matthew G. LaPorte, Tandy L. Draper, Lori E. Miller, Charles W. Blackledge, Lara K. Leister, Eugene Amparo, Alison R. Hussey, Dorothy C. Young, Srinivas K. Chunduru, Christopher A. Benetatos, Gerry Rhodes, Ariamala Gopalsamy, Torsten Herbertz,