Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1374345 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
Alkynyl- and azido-tagged 3-oxo-C12-acylhomoserine lactone probes have been synthesized to examine their potential utility as probes for discovering the mammalian protein target of the Pseudomonas aeruginosa autoinducer, 3-oxo-C12-acylhomoserine lactone. Although such substitutions are commonly believed to be quite conservative, from these studies, we have uncovered a drastic difference in activity between the alkynyl- and azido-modified compounds, and provide an example where such structural modification has proved to be much less than conservative.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Amanda L. Garner, Jing Yu, Anjali Kumari Struss, Colin A. Lowery, Jie Zhu, Sook Kyung Kim, Junguk Park, Alexander V. Mayorov, Gunnar F. Kaufmann, Vladimir V. Kravchenko, Kim D. Janda,