| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374372 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
A screening methodology called ‘genomic screening’ was established to identify natural products that can regulate cellular gene expression. Application of genomic screening to Keishi-bukuryo-gan (KBG), a Japanese herbal medicine formulation, identified a previously unnoticed transcriptional effect by linoleic acid, a known KBG component. The approach opens up a possibility to develop cell-permeable molecular tools for functional genomics research and sets a stage to evaluate the potential of natural products for transcription therapies.
Graphical abstractA new screening methodology was developed to uncover natural products that can regulate cellular transcription.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Akira Kawamura, Angelika Brekman, Yevgeniy Grigoryev, Tal H. Hasson, Anna Takaoka, Stephanie Wolfe, Clifford E. Soll,