Article ID Journal Published Year Pages File Type
1374381 Bioorganic & Medicinal Chemistry Letters 2006 5 Pages PDF
Abstract

The urokinase plasminogen activator is a trypsin-like serine protease, important in tumor development. Here, we report the synthesis and biochemical evaluation of selective and potent diaryl esters of phosphonic-type inhibitors for urokinase. We have found that the substituted phenyl ester ring has a strong influence on the inhibitory activity of these compounds. This led to the most potent phosphonic inhibitor for uPA synthesized to date.

Graphical abstractThe synthesis and biochemical evaluation of selective and potent diaryl esters of phosphonic-type inhibitors for urokinase and trypsin are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
, ,