Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1374381 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
The urokinase plasminogen activator is a trypsin-like serine protease, important in tumor development. Here, we report the synthesis and biochemical evaluation of selective and potent diaryl esters of phosphonic-type inhibitors for urokinase. We have found that the substituted phenyl ester ring has a strong influence on the inhibitory activity of these compounds. This led to the most potent phosphonic inhibitor for uPA synthesized to date.
Graphical abstractThe synthesis and biochemical evaluation of selective and potent diaryl esters of phosphonic-type inhibitors for urokinase and trypsin are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Marcin Sieńczyk, Józef Oleksyszyn,