Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1374387 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
Oleanolic acid and its synthetic derivatives have been identified as novel inhibitors of glycogen phosphorylase. Within this series of compounds, 4 (IC50 = 3.3 μM) is the most potent GPa inhibitor. Preliminary structure–activity relationships of the oleanolic acid derivatives are discussed.
Graphical abstractOleanolic acid and its synthetic derivatives have been identified as novel inhibitors of glycogen phosphorylase. Within this series of compounds, 4 (IC50 = 3.3 μM) is the most potent GPa inhibitor.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jun Chen, Jun Liu, Luyong Zhang, Guanzhong Wu, Weiyi Hua, Xiaoming Wu, Hongbin Sun,