| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374399 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
A series of highly potent and selective PPARδ agonists is described using the known non-selective ligand GW2433 as a structural template. Compound 1 is bioavailable, potent (10 nM), and shows no cross-activity with other PPAR subtypes up to 10 μM, making it a useful tool in studying the biological effects of selective PPARδ activation.
Graphical abstractA series of highly potent and selective PPAR agonists is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Robert Epple, Mihai Azimioara, Ross Russo, Badry Bursulaya, Shin-Shay Tian, Andrea Gerken, Maya Iskandar,