| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374400 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
A conjugate of DHA and doxorubicin (DHA–Dox) was synthesized, and its antitumor activity was evaluated in vitro against L1210 leukemia cells and in experimental animal tumor models including L1210 leukemia and B16 melanoma. DHA–Dox showed a greatly improved antitumor efficacy compared to free doxorubicin.
Graphical abstractSynthesis of a DHA and doxorubicin conjugate is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yuqiang Wang, Lianfa Li, Wei Jiang, Zhaoqi Yang, Zaijun Zhang,