| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374405 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
A series of rhodanine derivatives was synthesized and evaluated for their ability to inhibit PRL-3. Benzylidene rhodanine derivative showed good biological activity, while compound 5e was the most active in this series exhibiting an IC50 value of 0.9 μM in vitro and showed a reduced invasion in cell-based assay.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jin Hee Ahn, Seung Jun Kim, Woul Seong Park, Sung Yun Cho, Jae Du Ha, Sung Soo Kim, Seung Kyu Kang, Dae Gwin Jeong, Suk-Kyeong Jung, Sang-Hyeup Lee, Hwan Mook Kim, Song Kyu Park, Ki Ho Lee, Chang Woo Lee, Seong Eon Ryu, Joong-Kwon Choi,