Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1374409 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
Two new fluorinated imidazo[1,2-a]pyridine derivatives, 6-(2′-fluoroethyl)-2-(4′-dimethylamino)phenylimidazo[1,2-a]pyridine (FEPIP) and 6-(3′-fluoropropyl)-2-(4′-dimethylamino)phenylimidazo[1,2-a]pyridine (FPPIP), were synthesized. The binding affinity for FEPIP and FPPIP to amyloid plaques in human AD cortical tissues was determined. Radiolabeling, in vitro film autoradiography, and micro-PET study were performed with [18F]FPPIP to determine its utility as a radioligand for amyloid plaque imaging in the brain of AD patients.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Fanxing Zeng, Jeanine A. Southerland, Ronald J. Voll, John R. Votaw, Larry Williams, Brian J. Ciliax, Allan I. Levey, Mark M. Goodman,