Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1374421 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
The 3,4-fused sulfamides, sulfonamides and sulfone have been identified as highly potent γ-secretase inhibitors. Evaluation of the SAR of substitution within these series has allowed the identification of a range of compounds which significantly reduce brain Aβ in transgenic mouse models and thus have potential as possible treatments for Alzheimer’s disease.
Graphical abstractThe identification of a potent γ-secretase inhibitor, for example (ED50 = 0.06 nM), is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Duncan Shaw, Jonathan Best, Kevin Dinnell, Alan Nadin, Mark Shearman, Christine Pattison, James Peachey, Michael Reilly, Brian Williams, Jonathan Wrigley, Timothy Harrison,