Article ID Journal Published Year Pages File Type
1374421 Bioorganic & Medicinal Chemistry Letters 2006 5 Pages PDF
Abstract

The 3,4-fused sulfamides, sulfonamides and sulfone have been identified as highly potent γ-secretase inhibitors. Evaluation of the SAR of substitution within these series has allowed the identification of a range of compounds which significantly reduce brain Aβ in transgenic mouse models and thus have potential as possible treatments for Alzheimer’s disease.

Graphical abstractThe identification of a potent γ-secretase inhibitor, for example (ED50 = 0.06 nM), is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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