Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1374435 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
Inhibitors of phenylethanolamine N-methyltransferase [PNMT, the enzyme that catalyzes the final step in the biosynthesis of epinephrine (Epi)] may be of use in determining the role of Epi in the central nervous system. Here we describe the synthesis and characterization of 7-SCN tetrahydroisoquinoline as an affinity label for human PNMT.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Qian Wu, Joanne M. Caine, Stuart A. Thomson, Meri Slavica, Gary L. Grunewald, Michael J. McLeish,