| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374435 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
Inhibitors of phenylethanolamine N-methyltransferase [PNMT, the enzyme that catalyzes the final step in the biosynthesis of epinephrine (Epi)] may be of use in determining the role of Epi in the central nervous system. Here we describe the synthesis and characterization of 7-SCN tetrahydroisoquinoline as an affinity label for human PNMT.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Qian Wu, Joanne M. Caine, Stuart A. Thomson, Meri Slavica, Gary L. Grunewald, Michael J. McLeish,