| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374436 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
The development of a new class of CCR5 antagonist replacing the tropane core of maraviroc by piperidine with a branched N-substituent is described. Compound 15h shows good whole cell antiviral activity together with microsomal stability and only weak activity at the hERG ion channel.
Graphical abstractThe development of a new class of CCR5 antagonist replacing the tropane core of maraviroc by piperidine with a branched N-substituent is described. Compound 15h shows good whole cell antiviral activity together with microsomal stability and only weak activity at the hERG ion channel.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Christopher G. Barber, David C. Blakemore, Jean-Yves Chiva, Rachel L. Eastwood, Donald S. Middleton, Kerry A. Paradowski,